Oakland (1-6) at San Francisco (1-7), 8:20 p.m. on FOX and NFL Network. A pair of struggling Bay Area neighbors meet Thursday evening in Santa Clara as San Francisco, in last place in the NFC West, host struggling Oakland, last in the AFC West to open play in week nine. Both teams enter Thursday night’s prime time contest with losses under their belts.

Oakland and David Carr lost their third game in a row after Andrew Luck and the Indianapolis Colts left the Oakland Coliseum with a 42-28 win. The Silver and Black led 14-13 at the intermission after Colts K Adam Vinatieri made it a one-point contest with 26 seconds left, then watched the Colts outpace them 29-14 in the final 30 minutes of action. The Colts outrushed Oakland 222-103, with RB Marlon Mack leading the way with 132 yards and a pair of rushing TDs, while Raiders RB Doug Martin rushed for 72 yards in the contest. Passing-wise, Luck threw for 239, while Carr tallied 244 (each man threw three TDs without a sack or interception). The Raiders were 4 of 8 on third down, 1 of 2 on fourth down and kept the ball for 23:30, while the Colts had time on their side (apologies to Mick Jagger fans!) and held on to the ball for 36:30, going 9 for 13 on third down conversions.

The 49ers saw a 12-3 lead at the end of the third quarter escape from them as Arizona would score 15 fourth quarter points unchallenged to take an 18-15 win in Glendale last Sunday. San Francisco led the Desert Angry Birds by a baseball-like score of 5-3 at the break, then scored their lone TD of the contest when WR Marquise Goodwin and QB C.J. Beatherd connected on a 55-yard TD toss late in the third quarter. After the 49ers added a Robbie Gould field goal, Arizona then went to work in the final 15 minutes of action, with Josh Rosen connecting on TD passes to WR Larry Fitzgerald and WR Christian Kirk to give Arizona the lead for keeps. Arizona then held off a late 49er rally to come away with the win, while giving San Francisco their fifth loss in a row. While the 49ers did outrush Arizona 107-88, Rosen outpaced Beatherd, throwing for 252 yards with three sacks and an interception to go with the two TDs (Beatherd threw for 190 yards with four sacks and no interceptions). Third down tries? San Francisco was 5 of 15, Arizona was 6 of 14 at State Farm Stadium Sunday afternoon and the 49ers ruled the clock, keeping the ball for 32:19 to Arizona’s 27:41.

Oakland leads the series 7-6, while San Francisco has outscored the Silver and Black 291-240 (which includes contests that took place at Keezar Stadium, Candlestick Park and in Los Angeles). Oakland won the last meeting with San Francisco, taking a 24-13 win at home in 2014, while San Francisco’s last win in the series came in 2010 at Candlestick by a final of 17-9.

San Francisco’s favored by 3 and the over/under’s 46 1/2. These are two really bad teams and we wouldn’t blame you one bit if you watched “Young Sheldon” or “Greys Anatomy” instead of this contest. Pickiing a winner is like chugging castor oil. It’s not pleasant but it’s got to be done. san Francisco takes this one and covers the 3.

Broadcast Information – 8:20 p.m. on FOX, NFL Network and Amazon Prime: Joe Buck, Troy Aikman, Erin Andrews (Field reporter), Kristina Pink (Field reporter); NATIONAL RADIO: Westwood One: Tom McCarthy, Mike Holmgren; SIRIUS: 81 (Oakland), 83 (San Francisco); XM: 226 (Oakland), 225 (San Francisco)

Referee: Carl Cheffers

Injury Report

OUT: T Trevor Clemmings (Knee)
QUESTIONABLE: CB Gareon Conley (Foot), G Kelechi Osemele (Knee), CB Daryl Worley (Shoulder)

San Francisco
OUT: S Antone Exum (Concussion), LB Reuben Foster (Hamstring), S Jaquiski Tartt (Shoulder)
QUESTIONABLE: QB Casey Beathard (Right Wrist), RB Matthew Breida (Ankle), WR Pierre Garcon (Shoulder), RB Dominique Mostert (Ankle), C Weston Richburg (Knee), CB Richard Sherman (Calf)

Weather: Partly cloudy and 78 degrees

Broadcast Information and Injury Report courtesy the National Football League, odds courtesy Don Best, weather information courtesy The Weather Channel. (Note: Weather information is based on kickoff local time)