New England (2-2) at Tampa Bay (2-1), 8:25 p.m. on CBS and NFL Network. Week 5 kicks off on Thursday night at 8:25 p.m. Eastern on CBS/NFL Network/Amazon Prime with an interconference showdown in the Sunshine State as the Tampa Bay Buccaneers host the New England Patriots at Raymond James Stadium.

The defending Super Bowl champs lost their second game at home last Sunday, falling to Cam Newton and the Carolina Panthers 33-30 at Gillette Stadium. New England led 17-16 at the half before Carolina roared back in the final 30 minutes of action. Carolina would eventually take a 23-16 lead with 2:47 left in the third when Newton tossed a 16-yard TD pass to WR Devin Funchess. Newton, who threw for 316 yards and three TDs, would later score from seven yards out with 12:58 left in regulation.

New England would eventually pull even when Brady (307 yards, two TDs) and WR Danny Amendola connected on a 1-yard TD strike with 3:09 left. Carolina then went on to use that remaining 3:09, taking a 10-play, 46-yard drive that would send Pats fans home sad when Graham Gano, who missed an extra point earlier in the contest, booted a 48-yard field goal as time expired.
Carolina outrushed New England 140-80 and the Panthers were 6 of 9 on third down tries and held the ball for 28:53 (which included the final drive of the game), while the defending Super Bowl champs were 7 of 14 on third down (2 of 2 on fourth down) and kept the ball for 31:07.

Tampa Bay held off the winless New York Giants 25-23 at Raymond James Stadium last Sunday afternoon. The Buccaneers led 13-10 at the intermission before Eli Manning and the Giants took the lead with 3:16 left in regulation when he and TE Rhett Ellison connected on a 2-yard TD strike. The Giants missed the extra point and led 23-22 at that point. Tampa Bay then proceeded to make their way down the field, using all of the 3:16 on the clock, ending an 9-play, 59-yard drive that ended with K Nick Folk sending a 34-yard field goal try through the uprights for the win. Tampa Bay outrushed the Giants 111-91 and Winston threw for 332 yards and three TDs without an interception, while Manning threw for 288 yards and a pair of TDs in the Sunshine State. The Giants were 8 of 17 on third down tries and kept the ball for 34:13, while the Bucs were 3 of 11 on third down, keeping the ball for 25:47 (both teams were 0 for 1 on fourth down conversions).

The Patriots lead the series 6-2 and have outscored Tampa Bay 182-93. New England has won the last three meetings, including a 23-3 win in Foxboro in 2013, while Tampa Bay’s last win over Brady and the Pats came in 2000 by a final of 21-16 in Foxboro.

New England’s favored by 5 1/2 in the week five opener and the over/under’s 55 1/2. It’s Brady vs. Winston. One has a Heisman, the other has five Super Bowl rings. You might want to tape “Grey’s Anatomy” this week. New England covers the 5 1/2 in the Sunshine State and takes the win.

Broadcast Information: 8:25 p.m. Eastern on CBS and NFL Network – Jim Nantz, Tony Romo, Tracy Wolfson (Field reporter), Jay Feely (Field reporter); NATIONAL RADIO: Westwood One: Ian Eagle, Tony Boselli; SIRIUS: 88 (WestWood1), 81 (New England), 83 (Tampa Bay); XM: 88 (WestWood1), 81 (New England), 83 (Tampa Bay)

Referee: Carl Cheffers

Injury Report

New England
OUT: DB Eric Rowe (Groin), RB Rex Burkhead (RibS)
QUESTIONABLE: LB Elandon Roberts (Ankle), OL Marcus Cannon (Ankle), CB Stephon Gilmore (Ankle), LB Dont’a Hightower (Knee), DB Brandon King (Hamstring), WR Matt Slater (Hamstring), TE Rob Gronkowski (Thigh)

Tampa Bay
OUT: LB Kwon Alexander (Hamstring)
DOUBTFUL: LB Lavonte David (Ankle), S Keith Tanday (Hip), S T.J. Ward (Hip)

Weather: Cloudy and 77 degrees.

Broadcast information, officials, logo and injury report courtesy the National Football League, odds courtesy Don Best, weather information courtesy The Weather Channel.