Jacksonville (2-4) at Tennessee (3-4), 8:25 p.m. on NFL Network and Twitter. A pair of AFC South foes, chasing Houston, meet in the Music City to open play in week 8.

Both teams enter the Thursday night contest at Nissan Stadium with losses under their belts and both losses were at home.

Jacksonville could not get out of the gates against Oakland last Sunday at EverBank Stadium and came out on the short end of a 33-16 loss. The Jaguars trailed 20-6 at the half and found themselves being outscored by the Raiders 13-10 in the last 30 minutes of play. Jaguars QB Blake Bortles (246 yards, TD) was picked off twice in the loss, as Oakland outrushed Jacksonville 144-105.

The Titans led Indianapolis 23-20 with 6:02 left to play before letting that lead get away from them and fell to the Colts and Andrew Luck 34-26. Luck (353 yards, 3 TDs) and TE Jack Doyle teamed up for the TD that gave them the lead for good and Robert Mathis’ fumble recovery took place within eight seconds of each other and all but iced the game away for Indy in the fourth quarter. Tennessee’s Ryan Succop’s 44-yard field goal with 43 seconds left pulled the Titans to within eight but they could come no closer. De Marco Murray ran for 107 yards and a TD and Mariota threw for 232 yards and a pair of TDs but was sacked three times.

Tennessee leads the series 23-19 and have outscored Jacksonville 851-802. They split last year’s meetings, with each club taking wins at home.

They met in week 11 in Jacksonville and the Jaguars came away 19-13 winner at EverBank Stadium. Tied at 6-6 at the half, the Jaguars rallied fro a 13-9 deficit to score twice in the fourth quarter to take the lead for good. Tennessee outrushed Jacksonville 104-90 and Mariota threw for 231 yards but was sacked four times, while Bortles threw for 242 yards and a TD with an interception. Tennessee on third down tries went 5 of 13 and kept the ball for 31:35, while the Jaguars held the pigskin for 28:25, going 4 of 13 on third down tries.

Two weeks later… week 13… Music City and the Titans got their revenge on Jacksonville, coming away 42-39 winners at Nissan Stadium. Tennessee led 21-12 at the break, then held off Jacksonville in the second half as the Jagaurs would outscore Tennessee 27-21 in the final 30 minutes of action. This time, Mariota ran for 112 yards (Tennessee ran for 210, while they held Jacksonville to 81 yards on the ground) and threw for 268 yards and three TDs, while Bortles threw for 322 yards and five TDs. Both teams did quite well on third down conversions in the second contest, as Jacksonville was 10 of 14 and Tennessee was 8 of 13 (Jacksonville was 0 of 1 on fourth down) and time was on the side of Tennessee, who kept the ball for 33:34, while Jacksonville kept it for 26:26.

Tennessee’s favored by 3 1/2 in the Music City and the over/under’s 44 1/2. These are not bad teams, inspite their records. Still, we’ll understand if you want to watch “Big Bang Theory,” “Life In Pieces,” or “Grey”s Anatomy.” Tennessee covers the 3 1/2 at home in the Music City and takes the win.

Jim Nantz and Phil Simms along with reporter Tracy Wolfson call the action and are joined by kicking analyst Jay Feely.

At 6 p.m. on NFL Network, TNF GameDay Presented by KFC previews the Jaguars-Titans matchup from NFL Network’s studios in Los Angeles. Host Rich Eisen is joined by analysts Steve Mariucci, Marshall Faulk and Michael Irvin to provide news and analysis two hours before kickoff, while host Amber Theoharis and analyst LaDainian Tomlinson join from outside LP Field. Reporters Tracy Wolfson and Tiffany Blackmon join to provide the latest news leading up to kickoff.

At 7:30 p.m., NFL Thursday Night Kickoff airs from inside LP Field with James Brown, Deion Sanders and Bill Cowher. Coverage continues at 8 p.m with NFL Thursday Night Kickoff Presented by Tostitos providing the final say leading up to kick-off between Jaguars-Titans.

Among the pregame topics are:

•Deion Sanders and Bill Cowher take to the field to demonstrate how the Jaguars will slow down Titans quarterback Marcus Mariota

•Which team will win the AFC South?

•Preview of the Sunday night matchup between the Eagles and Cowboys

•How Lions quarterback Matthew Stafford has improved without Calvin Johnson

At halftime, Brown, Sanders and Cowher break down the first half on the Lexus Halftime show.

Immediately following the game, the Mazda Postgame show airs live on NFL Network from both Los Angeles and LP Field providing highlights, analysis and live interviews.

The entire 18-game Thursday Night Football schedule, including the live games and pre- and postgame shows, will also be streamed live on the NFL Mobile from Verizon app (NFL.com/mobile), the NFL app on XBOX, including interactive features from Microsoft, and through Watch NFL Network on tablets, PCs and various connected TV devices (NFL.com/watch), with participating television providers. Learn all of the ways to watch at NFL.com/TNF. An audio broadcast of the game is available on SiriusXM, TuneIn & Westwood One Radio Sports.

Thursday Night Football is available in Spanish via SAP (Secondary Audio Program) with Roberto Abramowitz calling the action on NFL Network.

Referee – John Hussey

Broadcast Information – 8:25 p.m. on NFL Network and Twitter: Jim Nantz, Phil Simms, Tracy Wolfson (Field reporter). Westwood One: Ian Eagle, Mike Mayock. SIRIUS: 83 (Jacksonville), 81 (Tennessee). XM: 226 (Jacksonville), 225 (Tennessee).

Injury Report

QUESTIONABLE: DE Jared Odrick (Quadricep), TE Julius Thomas (Ankle)

OUT: CB Perrish Cox (Concussion), S Julian Johnson (Neck), G Quinton Spain (Knee)
QUESTIONABLE: LB Kevin Dodd (Foot), WR Tajae Sharpe (Knee)

Weather Outlook: Mostly clear and 68 degrees

Broadcast information, officials and injury report courtesy the National Football League, odds courtesy Don Best, weather information courtesy The Weather Channel.