Denver (4-1) at San Diego (1-4), 8:25 p.m. on CBS, NFL Network and Twitter. A pair of AFC West rivals open play in week six of the 2016 season. Denver, knocked out of the ranks of the unbeatens, travels to Qualcomm for an AFC West showdown to open play in week 6.

Both teams enter tonight’s contest with losses under their belts. The defending Super Bowl champs trailed Atlanta throughout their contest last Sunday at Sports Authority Field at Mile High and fell to the Falcons 23-16. Atlanta led 13-3 at the intermission before the Broncos, with Paxton Lynch (223 yards) in at QB for Trevor Siemian (shoulder) launched a comeback that put Denver a little closer but not close enough. Denver was held to 84 yards on the ground, while Atlanta tallied 122 (DeVonta Freeman led all rushers with 88), while Atlanta’s Matt Ryan threw for 267 yards in the contest. Denver was 4 of 16 on third down tries, 4 of 4 on fourth down and kept the ball for 31:08, while the Falcons were 2 of 12 on third down conversions and 2 of 3 on fourth down, holding the ball for 28:52.

For San Diego, if it weren’t for bad luck, they’d have no luck. Once again, they carried a lead into the fourth quarter and like Wile Coyote, the lead fell off the cliff. This time, it was in Oakland against their AFC West rivals the Raiders. Leading 24-16 with 10:10 left to play in the third quarter, San Diego saw that lead get away from them as Oakland scored their final 25 points to take a 34-24 lead. The Chargers then responded with a 4-yard TD pass from Philip Rivers (359 yards)  to All Pro TE Antonio Gates to pull to within 3 at 34-31 with 6:21 left to play. San Diego then tried a 35-yard FG by Josh Lambo that would have tied things up and perhaps send the contest into overtime. As if things could not have gone worse for San Diego, the snap from center failed and holder Sean McGrath tried to run the ball in, to no avail. The attempt failed and Oakland got the ball back and after a Raiders punt, San Diego got the ball back with one last chance to take a win on the road. For the Chargers, they felt like Cinderella. The clock struck midnight, the coachmen turned back into mice and their carriage turned back into a pumpkin as several lateral passes failed and Oakland came away with the 3-point win.

Oakland outrushed San Diego 89-72 and David Carr threw for 317 yards and a pair of TDs, although he was sacked three times, while Rivers was sacked twice and threw a pair of interceptions. The Chargers, who suffered four turnovers, went 2 of 8 on third down tries (0 of 1 on fourth down) and kept the ball for 23:42, while the Raiders ruled the clock, keeping the ball for 36:18, going 5 of 14 on third down, 1 of 1 on fourth down.

Denver holds a 62-49-1 lead in the series (which includes games that took place when the Chargers were in Los Angeles), has outscored San Diego 2,413-2,407 and won 5 of the last six regular season meetings, including sweeping the series last year (San Diego’s last win over Denver came in 2013 when San Diego came away 27-20 winners in the Mile High City).

The first meeting… week 13 in San Diego and the Broncos held San Diego to a 51-yard field goal by Josh Lambo as they would take a 17-3 win at Qualcomm Stadium. The defending Super Bowl champs led by the 17-3 score at the break and both teams took it upon themselves to shut the other out in the second half. Denver outrushed San Diego 134-93 but Rivers managed to outpace Brock Osweiler (who was taking over for Peyton Manning) 202-186. Osweiler had the only TD pass in the contest, a 3-yard strike to WR Demaryius Thomas to open the scoring in the contest, while the Broncos’ defense chipped in with the other TD when LB Danny Trevathan picked off Rivers and returned the ball 21 yards for the second TD. Denver in the first meeting was 6 of 13 on third down tries and held the ball for 32:57, while the Chargers were 5 of 14 and 0 of 2 on third and fourth down, holding the ball for 27:03.

Meeting number two… week 17 in the Mile High City and the Broncos completed the sweep and took a 27-20 come-from-behind win at Sports Authority Field in the process. The Charger trailed 7-6 at the half and then took a 20-17 lead late into the final period of play before K Brandon McManus connected on a 35-yard field goal with 9:45 left in regulation. Denver would take the lead for keeps when Ronnie Hillman scored on a 23-yard TD run with 4:44 left. Hillman tallied 117 yards on the ground and Denver outrushed San Diego 210-110, while Osweiler outpaced Rivers 232-228 (Manning did enter the contest, going 5 of 9 for 65 yards). Despite turning the ball over five times, Denver managed to go 5 of 11 on third down tries and kept the ball for 25:28, while San Diego ruled the clock, keeping the pigskin for 34:32, while going 6 of 18 on third down and 0 of 2 on fourth down conversions.

Denver’s favored by 3 and the over/under’s 44 1/2. Siemian’s back under center and that’s a good thing for Broncos fans, who saw their hopes of running the table unblemished melt like a snowflake in the sun. For the Chargers, things don’t get any easier, as they get to go to the Big Peach next before a rematch with the Broncos in the Mile High City. Denver takes this one and covers the 3.

Jim Nantz and Phil Simms along with reporter Tracy Wolfson call the action, and are joined by kicking analyst Jay Feely.

At 6 p.m. on NFL Network, TNF GameDay Presented by KFC previews the Broncos-Chargers matchup from NFL Network’s studios in Los Angeles. Host Rich Eisen is joined by analysts Steve Mariucci, Marshall Faulk and Michael Irvin to provide news and analysis two hours before kickoff, while host Amber Theoharis and analyst Terrell Davis join from outside Qualcomm Stadium. Reporters Tracy Wolfson and Steve Wyche join to provide the latest news leading up to kickoff.

At 7:30 p.m. on CBS, NFL Network and Twitter, NFL Thursday Night Kickoff airs from inside Qualcomm Stadium with James Brown, Deion Sanders and Bill Cowher. Coverage continues at 8:00 PM ET with NFL Thursday Night Kickoff Presented by Tostitos providing the final say leading up to kick-off between Broncos-Chargers.

Among the pregame topics are:
•Feature on All-Pro Broncos cornerback Chris Harris Jr. The last three years have produced not only a career-defining Super Bowl championship but also the birth of his young daughters. Thursday Night Kickoff goes home with Harris to Parker, Colorado to see how he balances the demand of being a full-time athlete with those of being a full-time Dad
•Deion Sanders and Bill Cowher take to the field to demonstrate the Chargers’ gameplan against the Broncos’ defense
•Discussion of rookie defensive end Joey Bosa’s impact on the Chargers’ defense
•What have we learned about Broncos quarterback Trevor Siemian in his four starts?
•Does Chargers quarterback Philip Rivers have enough around him to turn the season around?

At halftime, Brown, Sanders and Cowher break down the first half on the Lexus Halftime show.

Immediately following the game, the Mazda Postgame show airs live on NFL Network, CBS and Twitter from both Los Angeles and Qualcomm Stadium providing highlights, analysis and live interviews.

Twitter will stream CBS’s broadcast of Broncos-Chargers, providing free, live streaming video on the Twitter platform on mobile phones, tablets, PCs and connected TVs. Fans can visit Twitter Moments or TNF.Twitter.com to view the live stream.

The entire 18-game Thursday Night Football schedule, including the live games and pre- and postgame shows, will also be streamed live on the NFL Mobile from Verizon app (NFL.com/mobile), the NFL app on XBOX, including interactive features from Microsoft, and through Watch NFL Network on tablets, PCs and various connected TV devices (NFL.com/watch), with participating television providers. Learn all of the ways to watch at NFL.com/TNF. An audio broadcast of the game is available on SiriusXM, TuneIn & Westwood One Radio Sports.

Thursday Night Football is available in Spanish via SAP (Secondary Audio Program) with Roberto Abramowitz calling the action on CBS and NFL Network.

REFEREE: Craig Wrolstad

Broadcast Information – 8:25 p.m. on CBS. NFL Network and Twitter: JJim Nantz, Phil Simms, Tracy Wolfson (Field reporter). Westwood One: Kevin Kugler, James Lofton. SIRIUS: 88 (WestWood1), 83 (Denver), 81 (San Diego). XM: 226 (Denver), 225 (San Diego).

Injury Report

Denver
OUT: LB DeMarcus Ware (Forearm)
QUESTIONABLE: QB Trevor Siemian (Shoulder), CB Kayvon Webster (Hamstring)

San Diego
Jahleel Addae S Collarbone Did Not Participate In Practice Out
Brandon Flowers CB Concussion Did Not Participate In Practice Out
QUESTIONABLE: T Joseph Barksdale (Foot), G Orlando Franklin (Ankle) T Christian Hairston (Groin), CB Craig Mager (Shoulder), RB Dexter McCluster (Hamstring), LB Denzel Perryman (Shoulder)

Weather Outlook: Sunny skies and 70 degrees.

Broadcast information, officials and injury report courtesy the National Football League, odds courtesy Don Best, weather information courtesy The Weather Channel.

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